4. Pulmonary Hypertension
Pulmonary hypertension (PH) is a debilitating condition manifested by pulmonary vascular remodeling, elevated pulmonary artery pressure, and right heart failure. One of the new areas of research in my lab is to identify whether neutrophil-platelet aggregation and platelet extracellular vesicles dependent pulmonary arteriole thrombosis contributes to progression of PH. We are conducting in vivo studies in rodents and in vitro studies with PH patient blood samples to identify the molecular pathways that promote neutrophil-platelet aggregation and thrombosis in pulmonary arterioles and test whether inhibiting these pathways at an early stage can prevent the vascular remodeling and cardiovascular morbidity manifested at later stages.