3. Joint-injury in hemophilia
Hemarthrosis is a major complication of hemophilia and ultimately leads to debilitating-painful-arthropathy, primarily affecting elbow, knee and ankle joints. Despite the development and implementation of factor replacement therapies that prevent acute joint bleeding, these events continue to occur, and the current therapy is limited to target joint-replacement surgery. My lab is conducting in vitro studies with hemophilia-A patient blood samples and in vivo studies in FVIII deficient (hemophilia-A) mice to understand how innate immune signaling in neutrophils and platelets contribute to progression of hemophilic arthropathy.